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Heinz-Josef Lenz Selected Research

Colorectal Neoplasms (Colorectal Cancer)

10/2022First-Line Nivolumab Plus Low-Dose Ipilimumab for Microsatellite Instability-High/Mismatch Repair-Deficient Metastatic Colorectal Cancer: The Phase II CheckMate 142 Study.
1/2022Genetic variants involved in the cGAS-STING pathway predict outcome in patients with metastatic colorectal cancer: Data from FIRE-3 and TRIBE trials.
1/2022Benefit from upfront FOLFOXIRI and bevacizumab in BRAFV600E-mutated metastatic colorectal cancer patients: does primary tumour location matter?
1/2022Assessment of Capecitabine and Bevacizumab With or Without Atezolizumab for the Treatment of Refractory Metastatic Colorectal Cancer: A Randomized Clinical Trial.
1/2022Tumor Immunogenomic Features Determine Outcomes in Patients with Metastatic Colorectal Cancer Treated with Standard-of-Care Combinations of Bevacizumab and Cetuximab.
1/2022Germline polymorphisms in genes maintaining the replication fork predict the efficacy of oxaliplatin and irinotecan in patients with metastatic colorectal cancer.
1/2022Molecular characteristics and clinical outcomes of patients with Neurofibromin 1-altered metastatic colorectal cancer.
1/2022Germline Polymorphisms in Genes Involved in the Antioxidant System Predict the Efficacy of Cetuximab in Metastatic Colorectal Cancer Patients Enrolled in FIRE-3 Trial.
1/2022Plasma Protein Biomarkers in Advanced or Metastatic Colorectal Cancer Patients Receiving Chemotherapy With Bevacizumab or Cetuximab: Results from CALGB 80405 (Alliance).
10/2021Molecular differences between lymph nodes and distant metastases compared with primaries in colorectal cancer patients.
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Heinz-Josef Lenz Research Topics

Disease

210Neoplasms (Cancer)
01/2022 - 01/2002
183Colorectal Neoplasms (Colorectal Cancer)
10/2022 - 01/2002
31Colonic Neoplasms (Colon Cancer)
10/2021 - 09/2004
23Adenocarcinoma
01/2021 - 08/2004
19Microsatellite Instability
10/2022 - 01/2007
18Disease Progression
10/2022 - 09/2004
16Neoplasm Metastasis (Metastasis)
01/2022 - 03/2006
14Stomach Neoplasms (Stomach Cancer)
01/2021 - 02/2006
14Rectal Neoplasms (Rectal Cancer)
12/2020 - 01/2005
12Exanthema (Rash)
10/2020 - 04/2005
10Pancreatic Neoplasms (Pancreatic Cancer)
10/2020 - 01/2003
10Breast Neoplasms (Breast Cancer)
01/2020 - 01/2003
8Carcinogenesis
03/2018 - 06/2003
7Leukemia
01/2022 - 11/2005
7Ovarian Neoplasms (Ovarian Cancer)
01/2022 - 03/2005
7Fatigue
10/2021 - 04/2007
7Neutropenia
02/2019 - 03/2006
7Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
11/2018 - 06/2004
7Hypertension (High Blood Pressure)
10/2018 - 08/2005
6Carcinoma (Carcinomatosis)
02/2021 - 03/2005
6Esophageal Neoplasms (Esophageal Cancer)
01/2018 - 01/2010
5Gastrointestinal Neoplasms (Gastrointestinal Cancer)
01/2020 - 02/2004
5Hepatocellular Carcinoma (Hepatoma)
11/2019 - 04/2007
5Diarrhea
12/2017 - 04/2007
4Circulating Neoplastic Cells
09/2021 - 03/2012
4Neuroendocrine Tumors (Neuroendocrine Tumor)
12/2020 - 07/2008
3Vomiting
10/2020 - 08/2004
3Nausea
10/2020 - 08/2014
3Lung Neoplasms (Lung Cancer)
07/2020 - 06/2004
3Cachexia
01/2020 - 01/2016
3Inflammation (Inflammations)
01/2020 - 01/2016
3Leukopenia
02/2019 - 07/2006

Drug/Important Bio-Agent (IBA)

52Biomarkers (Surrogate Marker)IBA
01/2022 - 08/2005
48Bevacizumab (Avastin)FDA Link
01/2022 - 09/2004
48Cetuximab (Erbitux)FDA Link
01/2022 - 09/2004
43Oxaliplatin (Eloxatin)FDA LinkGeneric
10/2022 - 06/2002
38Irinotecan (Camptosar)FDA LinkGeneric
10/2022 - 01/2003
36Fluorouracil (Carac)FDA LinkGeneric
01/2021 - 01/2002
35Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
01/2022 - 09/2004
32ErbB Receptors (EGF Receptor)IBA
01/2022 - 01/2005
27Pharmaceutical PreparationsIBA
10/2021 - 01/2003
23DNA (Deoxyribonucleic Acid)IBA
12/2020 - 01/2003
20Monoclonal AntibodiesIBA
05/2020 - 04/2005
18Messenger RNA (mRNA)IBA
10/2020 - 01/2002
17Proteins (Proteins, Gene)FDA Link
01/2022 - 01/2004
15Thymidylate SynthaseIBA
01/2019 - 01/2002
14GemcitabineFDA Link
10/2020 - 11/2002
14ParaffinIBA
11/2018 - 03/2005
12Leucovorin (Folinic Acid)FDA Link
01/2019 - 01/2003
11Interleukin-8 (Interleukin 8)IBA
04/2015 - 05/2005
10Capecitabine (Xeloda)FDA Link
01/2022 - 01/2002
10Immune Checkpoint InhibitorsIBA
01/2022 - 01/2017
10Biological ProductsIBA
11/2021 - 05/2007
10Formaldehyde (Formol)FDA Link
11/2018 - 12/2007
9regorafenibIBA
05/2021 - 01/2013
9Panitumumab (Vectibix)FDA Link
01/2019 - 01/2006
8PlatinumIBA
01/2022 - 11/2002
8LigandsIBA
01/2022 - 06/2007
8Epidermal Growth Factor (EGF)IBA
05/2020 - 07/2006
8AntibodiesIBA
01/2020 - 08/2011
7RNA (Ribonucleic Acid)IBA
01/2022 - 12/2008
7Phosphotransferases (Kinase)IBA
10/2021 - 04/2007
6trifluridine tipiracil drug combinationIBA
02/2019 - 05/2015
6Cyclooxygenase 2 (Cyclooxygenase-2)IBA
12/2018 - 05/2005
5NivolumabIBA
10/2022 - 01/2017
5B7-H1 AntigenIBA
01/2022 - 04/2015
5VorinostatFDA Link
01/2021 - 07/2009
5Histone Deacetylase InhibitorsIBA
01/2021 - 07/2009
5Immunoglobulin G (IgG)IBA
02/2018 - 01/2006
5Lapatinib (GW572016)FDA Link
01/2016 - 01/2009
5EnzymesIBA
11/2014 - 01/2002
5Cisplatin (Platino)FDA LinkGeneric
05/2012 - 01/2003
4Poly(ADP-ribose) Polymerase InhibitorsIBA
01/2022 - 03/2012
4Cell-Free Nucleic AcidsIBA
01/2021 - 08/2015
4Angiogenesis InhibitorsIBA
01/2020 - 12/2004
4Sorafenib (BAY 43-9006)FDA Link
01/2018 - 08/2005
4Thymidine PhosphorylaseIBA
11/2017 - 01/2002
4Erlotinib Hydrochloride (CP 358,774)FDA Link
06/2015 - 04/2005
4Codon (Codons)IBA
03/2015 - 03/2003
4Estrogen ReceptorsIBA
10/2013 - 01/2011
4PanobinostatIBA
08/2013 - 07/2009
4Vascular Endothelial Growth Factor Receptors (VEGF Receptors)IBA
03/2013 - 08/2005
4BilirubinIBA
08/2012 - 08/2004
4Bortezomib (Velcade)FDA Link
12/2011 - 01/2004
3IpilimumabIBA
10/2022 - 10/2018
3Calcibiotic Root Canal SealerIBA
01/2022 - 01/2019
3Histones (Histone)IBA
10/2021 - 08/2013
3MicroRNAs (MicroRNA)IBA
06/2020 - 09/2014
3Antineoplastic Agents (Antineoplastics)IBA
01/2020 - 01/2003
3human ERBB2 proteinIBA
01/2020 - 08/2013
3Vitamin DFDA LinkGeneric
12/2019 - 01/2018

Therapy/Procedure

99Drug Therapy (Chemotherapy)
01/2022 - 06/2002
88Therapeutics
01/2022 - 10/2003
14Immunotherapy
01/2022 - 01/2016
7Adjuvant Chemotherapy
11/2020 - 01/2003
5Lasers (Laser)
04/2009 - 09/2006
4Combination Drug Therapy (Combination Chemotherapy)
12/2020 - 06/2002
4Biological Therapy
12/2019 - 04/2014
4Neoadjuvant Therapy
01/2018 - 01/2005
4Radiotherapy
02/2016 - 05/2012